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Kaplan Qbank USMLE



Author4 Posts
  #1

Staging for Small CC is different b/c Surgical Resection is rarely done & Focus of Staging is to Uncover Metastatic Dis. that would "preclude" Aggressive Local Therapy to Chest & Prophylactic Radiation to the Brain hence do CT of Brain, Bone Scan....

Can somone pls explain the wrod "Preclude"

  #2

doyoudig wrote:
Can somone pls explain the wrod "Preclude"


keep from happening or arising; make impossible
prevent

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  #3

the think I didn't get is what do they mean by aggressive local treatment ? is is Local surgery?
Small CC is usully treated w/ Chemo b/c by the time it is Dx its already spread correct?




  #4

doyoudig wrote:
the think I didn't get is what do they mean by aggressive local treatment ? is is Local surgery?
Small CC is usully treated w/ Chemo b/c by the time it is Dx its already spread correct?

Well, the treatment plan is always Chemo- + Radiotherapy on tumor and mediastinum... Local sugery (something like a lumpectomy in breast cancer) is not given since SCLC is a central cancer araising from/around main bronchi... If surgery is considered, usually the pneumonectomy and bilateral mediastenal lymphadenectomy is preformed... Very long and technically complicated surgery (7-11 hours), and never endoscopic...
I am not sure if initial workout includes brain CT/IMR to exclude mets, but if they are found, usually total irradiation of brain cranium is given. Gamma-knife is not used because mets are usually numerous and progression of the disease is rapid...

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