monam84
Forum Senior
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A neoplasm in the colon invades through the basement membrane into the lamina propria. Which protein is most likely to be directly involved in the process of invasion? APC, p53, ras, Rb, type 4 collagenase
I was torn between type 4 collagenase and p53 I really need help on this one. FA says collagenase is used to invade, but I just feel like p53 should always be the answer. Thanks 
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| sss sss
Forum Senior
Topics: 8
Posts: 203
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type iv collagenase
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| doc179
Forum Guru
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Posts: 1,217
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p53 is a tumor suppressor gene it is involved in the formation of a tumor, I mean by nt doing its job. But since the qn asks what caused invasion its collagenase. Remember tumors metastasize because they have collagenase.
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| monam84
Forum Senior
Topics: 35
Posts: 135
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Thanks alot, I guess p53 isnt always the right answer 
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| me007
Forum Guru
Topics: 72
Posts: 803
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adenoma- to- carcinoma sequence is caused by mutation in APC tumor supressor gene.
(uw has few qs and schematic explanation)
p53 plays role in conversion late adenoma to adenocarcinoma
collagenase (metalloproteinase) associated with tumor cell invasion and neoangiogenesis
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| monam84
Forum Senior
Topics: 35
Posts: 135
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thank alot, i forgot that a carcinoma does not have to invade.
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