"asmi" wrote:
How does phenytoin cause B12 def. anemia ?
I meant how does phenytoin cause macrocytic anemia ?
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| dxtxpx
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Phenytoin in particular appears to decrease folate levels by interfering with its absorption in the small intestine as well as by accelerating its normal breakdown by the body
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| asmi
Forum Hero
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to be more specific...it actually inhibits intestinal conjugase, which is the jejunal enzyme converting polyglutamates into monglutamates .Thus,it causes folate deficiency---> macrocytic anemia.
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| dxtxpx
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thanks, point noted and saved somewhere in the brain :icon_heh:
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