asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
Can anybody differentiate anemia of chronic disease (ACD) vs iron def. anemia ( LAB DIAGNOSIS ) ?
|
| uscan
Forum Senior
Topics: 19
Posts: 88
|
-Iron deficiency-----:increased TIBC; decreased ferritin.
-Chronic disease----:decreased TIBC; increased ferritin.
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
ACD is the only condition where iron is decreased and ferritin is increased/normal. Usu ferritin goes first, followed by iron.
|
| meg
Forum Guru
Topics: 62
Posts: 806
|
yes, in ACD, the iron is trapped inside the cells because during infections, there is a production of a substance that does not let the ferritin out. So the Bone marrow senses that iron is still there and does not cause Transferrin increase.
Although the ferritin is high, it is of no use since it cannot come out, is like trapped inside, hence anemia.
|
| usmleasr
Forum Guru
Topics: 105
Posts: 970
|
yes good explanation meg thanks
|
| uscan
Forum Senior
Topics: 19
Posts: 88
|
:shock:
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
Next question: Is ACD microcytic or normocytic.
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
i think normocytic
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
Almost always...can be slightly microcytic, but rarely under 75.
|
| Bela
Forum Guru
Topics: 76
Posts: 412
|
Hmmm, so ACD is normocytic? Cuz I thought that this was the break down:
A) Normocytic w/decreased corrected reticulocyte count:
1)Aplastic Anemia
2)Renal Disease
B) Normocytic w/high corrected reticulocyte count: MAD
1) Membrane abnormality. Spherocytosis, Paroxysmal Nocturnal Hem.
2) Abnormal Hb. Sickle Cell Disease
3) Deficient enzyme. Glucose 6PD
and under Microcytics:
1) Fe def
2) ACD
3) Thalassemias
4) Sideroblastic Anemia (Pb poisoning, alcohol, B6 def)
Please explain!!! Thnx
___________________
La vita e bella!
|
| Sakaki-
Forum Senior
Topics: 1
Posts: 238
|
That breakdown looks fine, except that ACD is usually normocytic and normochromic (may occasionally be microcytic).
The etiology of ACD seems unclear, but red cell survival clearly decreases, and iron stores in the BM are increased, whereas serum iron is low.
|
|
| |
| | | | | | | | | | | |
