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Kaplan Qbank USMLE



Author15 Posts
  #1

38. A 69-year-old man comes to the physician because of a 6-month history of mild to moderate shortness of breath when climbing stairs. He had a myocardial infarction 2 years ago and has had an ejection fraction of 35% since then. His only medication is a beta-adrenergic blocking agent. The lungs are clear to auscultation. Cardiac examination shows an S4 gallop. There is no peripheral edema. Laboratory studies are within normal limits. An ECG shows no acute changes. Which of the following is the most appropriate pharmacotherapy?

A ) Angiotensin-converting enzyme (ACE) inhibitor

B ) beta-Adrenergic blocking agent

C ) Angiotensin2-receptor blocking agent

D ) Nitrates

sorry for the greek letter

E ) Thiazide diuretic

Edited by webjeee on 06/11/07 - 07:42 AM

  #2

B is more plausible. Not sure.

  #3

B bcz heat failure...decresed ejaction fraction




  #4

I think about ACEI too.
But just wondering how about ARB?
how to make choice between them? what situation ARB preferable over ACEI?

  #5

Why not a B-blocker?

___________________
First Aid is my Bible...

  #6

ejection fraction of 35%
again, His only medication is a beta-adrenergic blocking agent already.

  #7

It says his only med is an ALPHA-blocker.. (well actually my computer shows a weird "a" which i figured meant alpha!!!!)

___________________
First Aid is my Bible...

  #8

young_doc wrote:
It says his only med is an ALPHA-blocker.. (well actually my computer shows a weird "a" which i figured meant alpha!!!!)

sorry i put it as beta now

by the way, anyone can tell me what situation we pick ARB over ACEI.

  #9

There are evidence of clinical benefit supporting the use of ACEI, while we do not know for sure whether that apply to ARB; therefore ARB is used only when patient cannot tolerate ACEI.

webjeee wrote:

sorry i put it as beta now

by the way, anyone can tell me what situation we pick ARB over ACEI.



  #10

B ) Angiotensin-converting enzyme (ACE) inhibitor

___________________
Don't live in a town where there are no doctors

  #11

This is a classical case of heart failure. The ACA/AHA guidelines are very specific about this condition, i.e. people who have signs of structural heart defects and heart failure are to be started on ACE-inhibitors. Only if these are not tolerated, are they started on ARB´s, and, if these are not tolerated, on hydralazine & nitrates.
Additionally, once low-dose ACE-I´s have been instituted, a beta-blocker (which the patient is already on) can and should be started. Diuretics are here probably not indicated, as there are no signs of hypervolemia, i.e. lungs are CTA.
Additionally, thiazide is a first-line drug in hypertension, but not very potent in HF.

Correct answer: ACE-I, i.e. B.

  #12

This is heart failure so you give an ace inhibitor here have systolic dysfuction because the ef is less than forty percent but also an S4 is observed in diastolic dysfunction.

  #13

The ans is ACE inhib as it ttt of hrt failure consists of ACE,BB,& Diuretics
The ace will decerease the mortality so its your ans
i was worried about thiazide but since there are no signs of edema I'd go for ACE first
Angiot recept blockers aren't used as first line, the are only used in case of contraindicated or intolerable ACE--->Hyperkalemia & Intractable cough

  #14

nod

  #15

b) ACE Inhibitors

indications for use of ACE inhibitors post MI:
1. low ejection fraction (<40%)
2. LV dysfunction

if he doesnt tolerate ACE Inh, start ARB







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