asmi
Forum Hero
Topics: 1043
Posts: 4,609
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What is the MOA, adverse affects and uses ?
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| kiranmayi
Forum Guru
Topics: 237
Posts: 407
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inhibits Na-K-ATPase of cell membrane :arrow: increse in intracellular Na.
Na-Ca antiport does not function efficiently :arrow: increase intracellular Ca :arrow: +ve inotropy
Increase PR,Decrease QT,Scooping of ST segment,T wave inversion of EKG
Uses:CHF,atrial fibrillation
Adv effects:NVD.Blurry yellow vision,Arrhythmia.
Toxicities are increased by renal failure (decreased excretion)Hypokalemia(potentiates drug's effects)quinidine(decreased dclearance..displaces digoxin from tissue binding sites)
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