doc179
Forum Guru
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A clinical study is performed of subjects from birth to age 80 years who were documented by laboratory testing to have hypocalcemia. The medical records of these subjects are analyzed and the disease conditions documented in these subjects recorded. A subset of these patients had hypocalcemia documented in infancy. Which of the following conditions is most likely to have been present in this subset of patients?
A Parathyroid carcinoma
B Vitamin D deficiency
C Chronic renal failure
D DiGeorge anomaly
E Parathyroid adenoma
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| afrocaribb
Forum Senior
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hmmry, let me give it a try......i think it is Di george...cos they had hypocalcemia since childhood..here there is embrayonic failure to develop 3rd and 4th pharyngeal pouches which results in absence of parathyriod gland and thymus, the others i think will take a while b4 hypocalcemia will became evident.
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| new_n_lost
Politically InCorrect
Topics: 652
Posts: 6,066
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A Parathyroid carcinoma << Causes Hypercalcemia & is Least common in infancy
B Vitamin D deficiency << is a possiblity but pts dont have hypocalcemia (Rickets)
C Chronic renal failure << CRF not that prevalent
D DiGeorge anomaly <<< Well amongst the causes is more prevalent
E Parathyroid adenoma << Causes Hypercalemia
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| mytime
Kick my butt!
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D
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| doc179
Forum Guru
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(A) Incorrect. This is one cause for primary hyperparathyroidism. Such carcinomas are often associated with a very high calcium level.
(B) Incorrect. This is a cause for secondary hyperparathyroidism in which the serum calcium level may be normal to high, with a high serum phosphorus.
(C) Incorrect. This is a cause for secondary hyperparathyroidism in which the serum calcium level may be normal to high, with a high serum phosphorus.
(D) CORRECT. The deletion of chromosome 22q produces abnormalites in the 3rd and 4th pharyngeal pouches, which form thymus and parathyroids. The parathyroids may be absent in this condition, which can lead to hypoparathyroidism and hypocalcemia, as well as immunodeficiency from diminished cell mediated immunity. A partial DiGeorge syndrome is accompanied by less dramatic findings.
(E) Incorrect. This is a cause for primary hyperparathyroidism with hypercalcemia.
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