Mikeland
Forum Senior
Topics: 24
Posts: 109
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A 55-year-old male presents to his physician because of a large non-tender lump in his
neck that he noticed while shaving. A biopsy is performed that shows multiple large, round,
malignant cells with a high nuclear/cytoplasmic ratio in a background of mixed
inflammatory cells. The diagnosis of Hodgkin's disease is considered, and special stains are
ordered. Assuming the patient has Hodgkin's disease, the large malignant cells would likely
be positive for which of the following markers?
A. CD4
B. CD8
C. CD20
D. CD30
E. CD43
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| vradojc1
Forum Elite
Topics: 21
Posts: 309
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CD30 is expressed on Reed Sternberg cells
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| titly
Forum Elite
Topics: 17
Posts: 290
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| po
Forum Elite
Topics: 39
Posts: 356
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CD15 and CD30
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| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,056
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Immunologic studies of Reed–Sternberg cells from the nodular-sclerosing, mixed-cellularity, and lymphocyte-depleted types of Hodgkin's disease have revealed the presence of the lymphoid-activation markers CD30 and CD70 in nearly every case
http://content.nejm.org/cgi/content/full/333/14/9...
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| monam84
Forum Senior
Topics: 35
Posts: 135
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D. CD15, (CD30) Reed Sternberg cell
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| Mikeland
Forum Senior
Topics: 24
Posts: 109
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D
The classic Reed-Sternberg (RS) cell of Hodgkin's disease and its
variants, known as Hodgkin's cells, must be identified before the diagnosis of Hodgkin's
disease can be made. These cells are the neoplastic cells of the disease, and although many
theories have been postulated, the cell of origin remains unknown. The RS cell and RS
variants express CD30, a lymphoid activation antigen. CD15, a granulocyte antigen, is also
uniformly positive in RS cells.
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