kiranmayi
Forum Guru
Topics: 237
Posts: 407
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why ranitidine should not be given with sucralfate?
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| dxtxpx
Forum Guru
Topics: 259
Posts: 1,233
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sucralfate can decrease the absorption of ranitidine or any med-high potency antacids if administed concurrently
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| kiranmayi
Forum Guru
Topics: 237
Posts: 407
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Sucralfate is a promising drug that is not presently in widespread use because it is incompatible with H2 antagonists such as cimetidine, ranitidine, famotidine and nizatidine. Sucralfate is aluminum sucrose sulfate, a sulfated disaccharide, which polymerizes and binds to ulcerated tissue. It forms a protective coating against acid, pepsin and bile, giving the tissue a chance to heal. Unfortunately, a low gastric pH is required for polymerization, meaning that sucralfate is incompatible with drugs that reduce gastric acidity, such as H2 blockers and antacids.
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| usmleasr
Forum Guru
Topics: 105
Posts: 970
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yes ..it is rannitidine that inhibits sucralfate not the vice versa
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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and they fight because sucralfate needs different environment( PH matter) 
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