Justice
Just signed contract
Topics: 118
Posts: 2,369
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Man, that is easy:
The glomerular filtration pressure is determined by three main variables:
• systemic blood pressure
• vasomotor tone in the afferent arteriole
• vasomotor tone in the efferent arteriole
In cases of bilateral renal artery stenosis (or unilateral stenosis if there is only one functional kidney):
• the glomerular filtration pressure is dependent on the
vasoconstriction of the efferent arteriole because the resistance of the afferent blood vessels has been pathologically increased
• vasoconstriction of the efferent arteriole is mediated by angiotensin II
• administration of an ACE inhibitor abolishes the vasoconstriction of the efferent arteriole resulting in an abrupt fall in the glomerular filtration rate
• the deterioration in renal function due to ACE inhibitors is usually reversible on stopping the drug
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| niche
Forum Newbie
Topics: 7
Posts: 15
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got it,thanks for explaining.
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| doyoudig
Forum Guru
Topics: 144
Posts: 613
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nicely explained justice!
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