vradojc1
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From Hoffmann's Hematology:
The mechanism by which thrombosis occurs in PNH patients is not entirely understood, but similar to other manifestations of the disease, it is probably related to a GPI-anchored protein deficiency. In an attempt to repair damage, PNH platelets undergo exocytosis of the complement attack complex.[29] This results in the formation of microvesicles with phosphatidylserine externalization, a potent in vitro procoagulant. These prothrombotic microvesicles have been detected in the blood of PNH patients.[30] Fibrinolysis may also be perturbed in PNH given that PNH blood cells lack the GPI-anchored urokinase receptor.[31] The sites of venous thrombosis in PNH are manifold, and the abdominal veins and the cerebral veins are the most commonly involved regions.
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| Shaina
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thanks alot freind
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