carollyncheeyen
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Can anybody please explain:how does acetylcysteine work on that to prevent the liver toxicity?it's a mucolytic..
any other drugs that can be used?
thx.
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| new_n_lost
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Acetaminophen also is known as paracetamol and N-acetyl-p-aminophenol (APAP).
N-acetylcysteine (NAC). NAC is theorized to work through a number of protective mechanisms. NAC is a precursor of glutathione and increases glutathione availability to bind to NAPQI. It may also enhance sulfate conjugation of any unmetabolized APAP. NAC also functions as an anti-inflammatory and antioxidant and has positive inotropic effects. NAC increases local nitric oxide concentrations, and this vasodilatory effect on microcirculatory blood flow enhances local oxygen delivery to peripheral tissues. These vasodilating effects decrease morbidity and mortality even in the setting of established hepatotoxicity.
NAC Is the DOC in Acetoaminophen Toxicity along with Activated Charcoal
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| carollyncheeyen
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thx~!Juz read that Methionine preparations are also available as alternative for NAC~
also cuz it's the precursor for GSH.^^
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