new_n_lost
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pernicious anemia due to achlorohydria
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| Medusin
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No. Sorry...not according to my source.
Anyone else?
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| new_n_lost
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n ur source is ??
j/k but wud luv to know ur source
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| me007
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dilutional?
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| Medusin
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No...its not dilutional.
But could you explain your reasoning anyways?
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| Luckyall
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please, share with us what your source is saying...
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| epica
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ttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10518398&dopt=Abstract
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| sss sss
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i belive its macrocytic , though non megaloblastic as they have normal levels of folic acid and B12.just thinking does it have anything to do also with the heavy bleeding ie menstruation seen in hypothyroidism.
Edited by sss sss on 04/22/07 - 08:10 PM
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| new_n_lost
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Epica Can u repost the link cos it cant be opened plz.
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"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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INTRODUCTION: Anemias are diagnosed in 20-60% patients with hypothyroidism. Real values of the degree of anemia are estimated by radioisotopic analysis due to the lower volume of plasma in hypothyroidism causing false high levels of hemoglobin in blood. Anemia is often the first sign of hypothyroidism. Diagnosis of hypothyroidism should be considered in every case of anemia with uncertain etiology because sometimes signs of overt hypothyroidism needn't necessarily be evident. Microcytic, macrocytic and normocytic are regularly described anemias. CLASSIFICATION: Microcytic anemia is usually ascribed to malabsorption of iron and loss of iron by menorrhagia. Macrocytic anemia is caused by malabsorption of vitamin B12, folic acid, pernicious anemia and inadequate nutrition. Pernicious anemia occurs 20 times more frequently in patients with hypothyroidism than generally. Macrocytosis is found in up to 55% patients with hypothyroidism and may result from the insufficiency of the thyroid hormones themselves without nutritive deficit. Normocytic anemia, so-called uncomplicated anemia, arises due to thyroid hormones deficit itself not followed by nutritive deficit. This type of anemia is considered to be an adaptation to a decreased basal metabolism. Thyroid hormones directly or indirectly, through erythropoietin, stimulate growth of erythroid colonies (BFU-E, CFU-E). Normocytic anemia is characterized by reticulopenia, hypoplasia of erythroid lineage, decreased level of erythropoietin, mainly regular erythrocyte survival. Acanthocytosis findings in cytologic blood smear suggest hypothyroidism in about 90% of
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| new_n_lost
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Epica ...................So whts ur inference from the article
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"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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'Macrocytosis is found in up to 55% patients with hypothyroidism and may result from the insufficiency of the thyroid hormones themselves without nutritive"
Agree w you nnl
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| Medusin
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The answer is normocytic normochromic, because of lack of erythropoietin.
Patients with a variety of endocrine disorders that produce lower metabolic rates may develop a mild to moderate hypoproliferative anemia. The release of EPO from the kidney is sensitive to the need for O2, not just O2 levels, Thus EPO productios is triggered at lower levels of O2 tension in disease states (such ad hypothyroidism and starvation) where metabolic activity, and thus O2 demand, is decreases.
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| Medusin
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Reference: Harrisons Principles of Internal Medicine, 16th Edition
Chapter 90: Iron defiency and other hypoproliferative anemias page 592, 4th paragraph: ANEMIA IN HYPOMETABOLIC STATES
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| new_n_lost
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Other abnormal laboratory findings in hypothyroidism may includeincreased creatine phosphokinase, elevated cholesterol and triglycerides, and anemia (usually normocytic or macrocytic). Except when accompanied by iron deficiency, the anemia and other abnormalities gradually resolve with thyroxine replacement.
Harrison's 16th Edition pg 2111 Under Laboratory Findings 2nd Paragraph Line 8
U cant say that its only NormoCytic or Normochromic or Iron deficiency Anemia <= As My Good Friend says it " Anemia can be of Any Etiology depending upon the Stage of disease u have found the Pt."
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"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| Luckyall
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| Medusin
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Yes. You are right. Good discussion.
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| Medusin
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However I wanted to review the pathophysiologic mechanism responsible for anemia in a hypometabolic states such as hypothyroidism which (at least for me) helped me understand the problemas as a whole.
If you can see the relationship between the 02 levels, EPO and decreased metabolism then I think you are on the right track. Of course there are other etiologies such as metrorraghia and what not...
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