neo335
Forum Elite
Topics: 39
Posts: 174
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25y obese white female present s to ur office for evaluation of facial hair n irregular menstural cycles. she says she has been having amenorhoea for the past 4 mo. family history significant for idiopatic hirsutism. physicals normal.upt negative. serum DHEA is 5 ng/ml (N= 4.2ng/ml). to r/o pituatory n adrenal causes, ACTH stimulation test was performed n now DHEA level = 12 ng/dl. based on this , whats the most common diagnosis ?
A. PCOD ... B. androgen secreting ovarian tumour... C. cushing's disease .. D. cushing's syndrome E. adrenal Ca
answer is PCOD.
i read in kaplan but it hasnt mentioned about DHEA under PCOD. has just mentioned increase Testo n elavated LH/FSH . also i wantd to know if there wud b any of those ovarian tumours that release DHEA.. if there is an ovarian tumour like that, does it not release DHEA in responce to ACTH? please help me out to clear the concept here a bit.. i know UW may not havgiven the wrong answer.. but i havnt understood the thing well..
i thank u for ur time n wish u the best
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| Justice
Forum Fanatic
Topics: 101
Posts: 1,962
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Yes, this PCOD, aka Stein-Leventhal syndrome
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| usmle12
Forum Senior
Topics: 19
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well it has explanation in q bank normally level of DHEA are slightly elevated in pcod but in response to ACTH they increase but DHEA level is also high in adrenal tumor the differnce is that tumors are unresponsive to exogenous stimulations and only normal organs responds to acth....that is why tumors are mostly autonomous...i hope this clarifies
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| neo335
Forum Elite
Topics: 39
Posts: 174
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thank u USMLE12... so its the tumours that r autonomous while POCD do respond to the ACTH stimulation.. 
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