me007 wrote:
AML -
Auer rods
A vit (retinoic acid receptor gene fuse with PML)
t(15;17)
t (14;18)
Follicular lymphoma - B cell lymphoma and bcl-2 protooncogene activation
Rituximab - Rx for non-Hodgkin lymphomas,
AB against CD20
All good points, thanks!
A few secondaries I think are HY:
-AML-
What are the auer rods really?
Follicular Lymphoma
Chromosome 18 contains the bcl-2 protooncogene
What is the normal function of this gene?
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| afrocaribb
Forum Senior
Topics: 12
Posts: 146
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Auer Rods are fusion of myeloperoxidase +ve granulues in the myeloblast.
Bcl2 is a gene found on chromosome 18, it inhibits apoptosis by blocking the bax gene, normally when the bax gene is active it binds to the cell wall and creates a hole, cyt c can then leak out of the cell, cyt c activates a n enzyme called Apaf 1 which in turn Activates caspases that will digest and kill the cells, hope this helps.
Edited by afrocaribb on 04/21/07 - 05:01 AM
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| Ig F
Forum Elite
Topics: 3
Posts: 431
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Auer Rods are spindle shaped inclusions which are made up of myeloperoxidase +ve granulues in the myeloblast and they are the pathagnomonic for AML of M3 type acc. to FAB classification...
Bcl 2 gene is an antiapopttotic gene as it inhibitz BAX gene which normally when active form holes in the cells and release and activate toxic enyme killing the malignant cells.....
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