kiranmayi
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Loss of which of the following classes of molecules on the surface of a tumor cell target would result in loss of susceptibility to killing by host immune cells?
A. CD3
B. CD4
C. CD8
D. MHC class I
E. MHC class II
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| asmi
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C.. :?:
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| kiranmayi
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The correct answer is D. After the MHC class I molecule has moved to the surface of the tumor cell, peptide fragments from the tumor are presented in a groove of the class I molecule. The peptide fragments are presented to cytotoxic CD8 T cells, which recognize the MHC class I molecules on the cell surface and kill the tumor cell. Loss of this molecule would therefore prevent the tumor cell from being killed.
The CD8 molecule (choice C) is not on the surface of a tumor cell, but it is on the surface of a CD8+ cytotoxic T lymphocyte.
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| asmi
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thanks
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