new_n_lost
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An 18 year old male presented with delayed pubertal development. He had always noted an impaired sense of smell. Examination revealed that his height was on 90th percentile and his weight on the 90th percentile. His external genitalia showed a small penis with testicular volumes of 3 mL bilaterally and no pubic hair.
Investigations revealed:
LH concentration 1.0 U/L (1-10),
FSH concentration 1.0 U/L (1-7),
Serum testosterone 3.0 pmol/L (9-35),
Free T4 19 pmol/L (10-22),
TSH 3.0 mU/L (0.4-5),
CT scan reported as normal.
What is the most likely diagnosis?
1) Constitutional delay of puberty
2) Kallmann's syndrome.
3) Klinefelter's syndrome.
4) Noonan's syndrome.
5) Prader-Willi syndrome
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| mms
Forum Junior
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2) ?
deficiency of GnRH by the hypothalamus
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| doc179
Forum Guru
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2
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| Addicudo
Forum Guru
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2) Kallmann's syndrome .. Anosmia associated with congenital hypogonadism .. Diagnostic FSH and LH levels .. (Low) !
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| new_n_lost
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Politically InCorrect
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The combination of hypogonadotrophic hypogonadism and anosmia would suggest a diagnosis of Kallmann’s syndrome. This is one of the commonest causes of isolated hypogonadotrophic hypogonadism annd is due to a failure of migration of the olfactory neurones and GnRh neurones during development.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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