new_n_lost
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A 21 year old female with epilepsy is well controlled on sodium valproate 600mg bd and had been taking oral contraceptives for three years. She presented to her general practitioner 12 weeks pregnant.
Which of the following is correct?
1) An alternative anticonvulsant should be used in place of sodium valproate
2) Interaction of sodium valproate with the oral contraceptive increased the risk of pregnancy
3) The dose of sodium valproate should be increased
4) There is an increased risk of a neural tube defect in her fetus
5) She is at increased risk of anemia in pregnancy
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| salmonella
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4..spina bifida
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| asherif
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 4..spina bifida
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| new_n_lost
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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There is an increased risk of neural tube defects associated with anti-convulsants during pregnancy. However, the risks associated with treatment are outweighed by the benefits in preventing seizures, so the drug should be continued. The risks may be minimized through use of folate supplements. Sodium valproate is not an enzyme inducer and would not speed up metabolism of the pill.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| lq2006
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