usmleasr
Forum Guru
Topics: 105
Posts: 970
|
how do u treat..nephrogenic DI? and SIADH...?
|
| dxtxpx
Forum Guru
Topics: 259
Posts: 1,233
|
central DI: vasopressin
nephrogenic: thiazide diuretics, NSAIDS
SIADH: demeclocycline
|
| usmleasr
Forum Guru
Topics: 105
Posts: 970
|
SIADH ..WATER DEPRIVATION..  ...also...but what si the rationale of using diuretic in a condition DI..where there is already water loss.. :roll:
|
| krsma
Forum Elite
Topics: 40
Posts: 227
|
I'm confused also, can someone please explain. thanks
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
An interesting combinational medicinal regimen discussed in one source of literature is Hydrochlorothiazide, a diuretic, and indomethacin or desmopressin (vasopressin).
:arrow: Hydrochlorothiazide reduces the total urine output by causing more sodium and more water to be reabsorbed in the proximal convoluted tubules than normal; this leaves less fluid available for the distal tubules, the portion affected by NDI, to excrete and thus the total volume of urine that can be excreted is reduced.
:arrow: Another treatment of Diabetes insipidus is to give either hydrocortisone or prednisone. This reduces the swelling of the nuerohypophisis area.
|
| asmi
Forum Hero
Topics: 1043
Posts: 4,609
|
about desmopressin taken either orally or as a nasal spray, has proven effective in significantly decreasing urine output, increasing urinary osmolality, and normalization of plasma osmolality. Of course this only works for hypothalamic diabetes insipidus, because individuals affected with nephrogenic DI often do not have functioning recpetors for vasopressin.
|
| bright_nnn
Forum Senior
Topics: 17
Posts: 97
|
Very Good Asmi
|
|
| |
| | | | | | | |
