Feyza
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Kaplan says : main target LIVER for pseudomonas aeruginosa...what does pa got to do with the liver ?!???!?!?
and did u know pasteurella and b.fragilis had capsules too 
and also keep in mind that mycobacterium leprae is an OBLIGATE intracellular mo...
details I noticed in my second reading of micro :/ wanted to share just in case u come into 
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| Feyza
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no comments on the liver stuff ??
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| monam84
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how does pa present clinically in the liver? What type of problems does it create in the liver?
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| GoodGirl
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Must be a mistake, does not give a sense to me !
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| Feyza
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yeaa...I would ignore if it wasnt Kaplan where I read it 
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| new_n_lost
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In the US: According to data from the Centers for Disease Control and Prevention (CDC) National Nosocomial Infections Surveillance System of 1996, P aeruginosa can be rated as follows:
- Number 1 cause of intensive care unit (ICU)– related pneumonia
- Number 1 cause of osteochondritis
- Number 2-ranked gram-negative organism, responsible for 9% of all nosocomial bacterial and fungal isolates
- Number 2 cause of nosocomial pneumonia
- Number 3-ranked isolate in hospital-acquired UTIs
- Number 4 cause of surgical site infections and of hospital-acquired gram-negative rod bacteremia
- Number 5 hospital pathogen
- Number 8-ranked bloodstream isolate
- Most common bacteria isolated from mild-to-severe form of external otitis and chronic suppurative otitis media
- Most common gram-negative organism isolated from corneal ulcers and endocarditis
- Frequent cause of contact lens–associated keratitis
- Second most frequent cause of brain abscess and meningitis in patients with cancer
- Third most common cause of recurrent UTIs complicated by obstruction, catheters, or stones
- Fifth most common cause of recurrent UTIs in schoolchildren
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| mytime
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Hey girls liver is primary target coz it's an oxidase positive bug which gets its energy from suger oxidation via electron transport by cytochrome c. JAWETZ.
And btw besides UTI it seems infections by Psuedomonas can be caused everywhere.
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| bactitech
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I'm not sure where that liver thing comes from. I can't tell you the last time I saw a Ps. aeruginosa growing in liver tissue. We commonly see them in urines, respiratory specs, and occasional blood cultures. I would say that the list posted by new_n_lost is pretty close to reality.
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| Feyza
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ok...I decided to forget about the liver  Ill stick to the info I have ...the ones nnl repeated...thanx guys
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| GoodGirl
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Year later found out about the concept behind the Kaplan sentence : Liver is the primary target for Pseudomonas.
Pseudomonas exotoxin A (PEA) is an extracellular virulence factor produced by the opportunistic human pathogen Pseudomonas aeruginosa. PEA intoxification begins when PEA binds to the low-density lipoprotein receptor-related protein (LRP). The liver is the primary target of systemic PEA, due largely to the high levels of functional LRP expressed by liver cells.
http://cat.inist.fr/?aModele=afficheN&cpsidt=...
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| taipei817
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the pseudomona actually does target liver as C. diptheria targets the heart, these 2 have simliar toxins but different targets. i remember reading this from microbiology-rediculous book.
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