keepgoing
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All of the following statements regarding B-lymphocytes are true except
1. they secrete antibodies when helped by T cells
2. They differentiate into plasmcytes
3. Their antigen receptor is monomeric IgM
4. They function as ACPs
5. They mature in bone marrow
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| new_n_lost
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3. Their antigen receptor is monomeric IgM
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| jole
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5. They mature in bone marrow
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| usmlefever
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no.5
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| keepgoing
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Answer is 1
B-Lymphocytes do not require always help from T-helpers in order to response to produce antibodies.T-independent antigens .such as polysaccharides that comprise bacterial capsule,are not readily processed and presented to T-helpers.However these type of antigens can directly activate B-cells by crosslinking B-cell antigen receptors.crosslinked antigens gets aggregated at one pole of cell by the process called "capping"resulting in transmission of single sufficent for B-cell activation.Nearly all of teh antibody produced is M(IgM) and kinetic of production resemble a primary response.B-cell differentiation occurs in two phases1. antigen independent phase and 2nd antigen dependent phase,during which activated B-cells differentiated into antibody-secreting plasmcytes.
Monomeric IgM embbeded in cytoplasm membrane of each immunocompetent B-cells and acts as highly specific B-cell antigen receptor.in addition to the seretion of antibodies B-cells acn present antigen to CD4+ T-cells.the surface IgM efficiently traps antigen which is then engulfed by B-cells by endocytosis9B-cells are not capable of phagocytosis).the engulfed antigen is processed and critical peptides are present on the B-cell surface in teh context of major histicompatible complex( MHC) class II molecule.
The bone marrow,central lymphoid organ,is the major site of B-cell maturation and the maturation process involves assistance from bone marrow stromal cells.
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| jole
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Thanks Keepgoing for the answers and nice explanations.keep up the challenge and All the best.
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| keepgoing
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Sure jole!!!thanks  ..GL to u as well!
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| dr ruman
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nice work
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| Jackofknives
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Man this question is poorly phrased
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