salmonella
Forum Elite
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where is the defect?
Irregular, patchy cafe-au-lait spots, especially on the back
Vaginal bleeding (first menstruation) at a very early age
Premature puberty
early breast development
early pubic and armpit hair development
Some patients get more broken bones
Rarely, a form of gigantism (overgrowth of the body caused by excess hormones)
Signs and tests Return to top
A physical examination may show signs of:
Hyperthyroidism (occasionally)
Adrenal abnormalities (occasionally)
Acromegaly (occasionally)
Cafe-au-lait spots of the skin
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| new_n_lost
Politically InCorrect
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McCune-Albright syndrome is the result of a postzygotic somatic mutation in the gene coding for the alpha subunit of the stimulatory G protein (Gsa). G proteins couple cell surface receptors to intracellular proteins to activate or inactivate signaling cascades.
The stimulatory G protein is normally activated when a hormone or other ligand binds to the cell surface receptor. The activated Gsa subunit subsequently disassociates from the receptor, binds to adenylyl cyclase, and stimulates an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. The Gsa subunit then is inactivated, reassociates with the receptor, and is again available for hormone-mediated reactivation.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| salmonella
Forum Elite
Topics: 45
Posts: 265
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thanks a lot buddy
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Allah he Allah kia kero, Allah he say dara kero!!!!
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| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
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Ur R Welcome
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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