docnikki
Forum Guru
Topics: 93
Posts: 680
|
Friends I believe that parvo B19 has something to do with hemoglobinopathies...but heriditary spherocytocis is not a hemoglobinopathy..then whats parvo B19 doing here in the Herid spherocytocis question...
plz take a look and give your oppinion. I have no doubt about the answer..but just worried about why is parvoB19 here!
Attached Files:
HS.doc (110 KB, 37 downloads)
|
| doc_clotaire
Forum Guru
Topics: 159
Posts: 1,301
|
Indeed A
The patient has hereditary spherocytosis for sure ( osmotive fragily test is positive ) His father died probably from a splenectomy ( typical family history ) and his son also has the disease .
Contrarly as we were taugh from Step 1 , Parvovirus B19 can cause aplastic anemia not only in hemoglobinopathies like sickle cell but also in hemolytic anemia like hereditary spherocytosis . That ' ve been proved in clinical trials and Thi is Big time now
Any more input is welcome !
___________________
The elevator to succes is broke ,you must take the stairs
|
| Justice
Just signed contract
Topics: 118
Posts: 2,369
|
Some more evidence:
J Ark Med Soc. 1997 Sep;94(4):163-4. Related Articles, Links
Aplastic crisis associated with parvovirus B19 in an adult with hereditary spherocytosis.
Beland SS, Daniel GK, Menard JC, Miller NM.
Department of Internal Medicine, UAMS, USA.
Parvovirus B19 is usually associated with an acute, self-limited disease in children. In patients with a congenital hemolytic anemia, infection with this virus can cause an aplastic crisis. We describe such a crisis in an adult with asymptomatic hereditary spherocytosis. The association between acute red blood cell aplasia and infection with parvovirus B19 is well described in patients with hereditary hemolytic anemia, particularly sickle cell anemia. This association has also been described, although less frequently, in patients with other inherited hemolytic diseases, such as hereditary spherocytosis. In children, human parvovirus B19 causes an acute self-limited illness known as erythema infectiosum (fifth disease). In immunocompromised individuals, chronic infections can occur and cause a severe, persistent anemia. In pregnant women, infection can, but usually does not, lead to fetal infection. An infected fetus can have severe anemia, congestive heart failure, generalized edema (fetal hydrops) and even death. Most cases of aplastic crises associated with parvovirus B19 in patients with hereditary spherocytosis have been reported in children and adolescents. In this paper we describe an aplastic crisis in a 28 year old man with asymptomatic hereditary spherocytosis.
Publication Types:
* Case Reports
___________________
The winner takes it all...
|
| Justice
Just signed contract
Topics: 118
Posts: 2,369
|
And the treatment is (A), agree...
___________________
The winner takes it all...
|
| Justice
Just signed contract
Topics: 118
Posts: 2,369
|
And here is the PubMed link to a number of abstracts showing role of PV19 in HSC.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=...
___________________
The winner takes it all...
|
| docnikki
Forum Guru
Topics: 93
Posts: 680
|
thanks dr_clotaire and Justice. that cleared my confusion. that abstract was very helpful justice  . thanks for the effort. GL.
|
| sprint123
Forum Guru
Topics: 129
Posts: 870
|
Hey docnikki..Can you tell me why we use folic acid for many of the hemolytic disorders??
|
| docnikki
Forum Guru
Topics: 93
Posts: 680
|
sprint123, we use folic acid because in hemolytic disorders the Bm can compensate and produce more cells that are being distroyed and its compensation often is limited by the folic acid reserves which if not supplemented can lead to rappid depletion of cells. Fe can be recycled and B12 is not depleted that soon. hope taht helps. GL
|
|
| |
| | | | | | | | |
Similar forum topics