doc179
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Please see the attached file for the qn.
Thanx.
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| new_n_lost
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A is the Answer
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| keepgoing
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 no one has yet posted anything...nnl plzz help,this thing making me anxious now...i dont question ur chosn ans but i need to recall in general low binding protein doesnt it mean either liver malfunctioning or high circulating hormones for which available BPs get short of???good questions doc179 where are these from,if u dont mind sharing ??
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| doc179
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Hi KG I am not very sure where these qns are from, but i got them from a friend. They are most likely from physio qbank.
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| doc179
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NNL is right about the answer. I had gone for the choice C thinking that they are talking about the IGF-1 receptor. But they are talking about the IGF-1 binding protein. Yes, if the binding protein is decreased IGF-1 will also decrease.
Edited by doc179 on 04/10/07 - 04:58 PM
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| epica
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1 How Sulfonylurea drug will influence GH?
Mech-sm?
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| new_n_lost
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Guys i choose the Answer on one basis only the IGF 1 has a binding protien to which its bound to in circulation 95% of it if the binding protein is dec then there is no way there is going to be a Increase level of IGF1. Secondly the If ur GH levels r decreased then ur IGF 1 levels also decrease.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| doc179
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oh God, I have been so careless. only after reading your last post NNl I realised that I have been reading the question and understanding it wrongly. I have been thinking I dont know why that they are talking about the receptor , but they are talking about the binding protein. hmm...I should be more attentive and alert. Thanx NNL. I have edited my last post friends as I was talking about the receptor there as well. 
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| new_n_lost
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Sulfonylureas also cause the decrease of serum glucagon and potentiate the action of insulin at the extrapancreatic tissues. i.e if we have functional Beta cells hten these Sulfaonylureas will work at optimal best. Insulin also has a permissive action on GH.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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| keepgoing
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ok thanks guyz my question was about free and bound in gen.anyways doc179 n nnl thanks..!
Edited by keepgoing on 04/12/07 - 12:21 AM
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| drduck
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hey i didnt get it.....i mean if the answer is C then there must be a rise in the level of IGF1, but the senario is showing that growth of the child is very slow.....
cud anyone help me out with this one.....as everything else is normal and since they have not given the levels of GH, we got to consider it as normal....associated finding is normal T3 and T4 levels.
also tell me which disorder are u thinking about...
i dont know whether there is something special about this binding protein 3 (in all 7), and so i feel the answer might be D.
personally i dont think this Q is as simple as it seems.....
tell me the answer plz.
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| doc179
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drduck the answer is A and I have also attached the file with explanation, pls go thru it.
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| drduck
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hey thanks a lot 179,
but i didnt understand what hapens when the binding protein in the plasma falls.........i mean the free level of hormone increases or does it decrease???
i m abit confused....when binding protein level falls the drugs bound to them get free and the concentration of the drug in plasma rises and it may even rise to toxic level.
so if the IGFBP3 level falls level of IGF1 shud rise and child shudnt have growth retardation..
i think i m gettin too much in this Q but....
plz clear my doubts
thanks
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| doc179
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you are right about the drugs. But not about the GH. GH stimulates the production of both IGF-1 and its binding protein. and IGF-1 being water soluble is always protein bound. Hence binding protein is deficient then you obviously know that GH is deficient and hence IGF-1.
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| lq2006
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A
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