asmi
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A 28-year-old woman comes to the physician because of an increased vaginal discharge that has an unpleasant odor.
She states that the symptoms started 2 days ago and have been worsening since. Other than the malodorous discharge, she has no other complaints. Past medical history is significant for occasional migraine headaches. Past surgical history is significant for tonsillectomy as a child. She takes no medications regularly and has no known drug allergies. Speculum examination demonstrates a homogeneous, grayish-white discharge, partially adherent to the vaginal walls. There is no edema or erythema of the cervix, vagina, or vulva. A drop of the vaginal discharge is tested for pH, which is 4.9. When potassium hydroxide (KOH) is added to the discharge, there is an intense amine odor. A normal saline wet preparation of the discharge reveals a predominance of clue cells.
1.Which of the following is the most likely diagnosis?
/ A. Bacterial vaginosis
/ B. Candidiasis
/ C. Chlamydia
/ D. Gonorrhea
/ E. Trichomoniasis
2.The patient is started on metronidazole. This medication works via which of the following mechanisms?
/ A. Binds 50s subunit of bacterial ribosome and inhibits translocation of the peptide chain from the A site to the P site
/ B. BIocks cross-Iinking of the N-acetyl muramic acid/N-acetyl glucosamine backbone by binding to D-ala-D-ala
/ C. Inhibits DNA-dependent RNA polymerase by binding to the subunit and inhibiting initiation
/ D. Interferes with DNA gyrase activity and prevents the winding of DNA helix into the supercoiled form
/ E. Is reduced to a substance that inhibits cellular DNA synthesis
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| dxtxpx
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A & E
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| asmi
Forum Hero
Topics: 1043
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correct SIR 
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| dxtxpx
Forum Guru
Topics: 259
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hey I am not a sir, I am a girl and I dont like the word 'ma'm' either 
For this Q: metronidazole indication mnemonic from FA
GET on A METRO
Giardia/Gardnerella
Entamoeba
Trichomonas
Anaerobs (bacteroides, clostridum)
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| asmi
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