Addicudo wrote:
Jackofknives Posted May 24, 07 - 21:52:
Its very unlikely to have 2 unrelated persons to have allels with the same mutation.
Think of it this way, what are the odds of 2 DNA molecules which consists of millions of bps have to the same point mutation on the same locus. Yes, extremely rare. .. But hey Jack .. if there aint the same Mutation in the SAME ALLELE .. wont an AUTOSOMAL RECESSIVE disease ... NOT express itself .. ???
Its more common for people with a autosomal recessive condition to have heterogeneous mutations on the two allels that you have on the homologous chromosomes, or for the same protein for that matter. Say 4q32 codes for an important protein, you may have recieved a point mutation there from your father and a frame-shift mutation from your mother, the end result is abberant production of this essential protein rendering it useless. This case is much more common among patients who parents are not related to each other.
___________________
There are many things in this world that can’t be changed no matter how hard you try. That’s why you must not hesitate when the time comes where you have to give it all you’ve got.
|
| mytime
Kick my butt!
Topics: 39
Posts: 3,173
|
Aha I didn't even know there was a discussion going. haven't I already said Yes to D?????
|
|
| |
| | | 
