asmi
Forum Hero
Topics: 1043
Posts: 4,609
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* what is the precursor?
* what are its effects?
* site of synthesis ?
* deficiency lead to what ?
* excess synthesis leads to what ?
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| dxtxpx
Forum Guru
Topics: 259
Posts: 1,233
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Serotonin (5hydroxytryptamine, 5HT) is synthesized from L-tryptophan; chief metabolite is 5-hydroxyindoleacetic acid, 5HIAA)
[/B]5HT1: stimulation is associated with contraction of arteriolar smooth muscle; presynaptically inhibits release of 5HT
5HT2: stimulation is associated with contraction of vascular and intestinal smooth muscle; platelet aggregation; in CNS: hallucinations
5HT3: Vomiting; in peripheral neurons: pain
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| anne
Forum Elite
Topics: 41
Posts: 348
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Excess synthesis leads to carcinoid syndrome characterized by flushing,diarrhea,cramping,bronchospasm,wheeze,telangiectasia,cardiac fibrosis etc. It may also lead to niacin deficiency because much tryptophan is consumed in serotonin synthesis,leading to pellagra.
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| anne
Forum Elite
Topics: 41
Posts: 348
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Excess synthesis leads to carcinoid syndrome characterized by flushing,diarrhea,cramping,bronchospasm,wheeze,telangiectasia,cardiac fibrosis etc. It may also lead to niacin deficiency because much tryptophan is consumed in serotonin synthesis,leading to pellagra.
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| Aishvarya
Forum Newbie
Topics: 4
Posts: 32
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Serotonin (5-hydroxytryptamine, 5HT) is formed by the hydroxylation and decarboxylation of tryptophan.
The greatest concentration of 5HT (90%) is found in the enterochromaffin cells of the gastrointestinal tract. Most of the remainder of the body's 5HT is found in platelets and the CNS.
The effects of 5HT are felt most prominently in the cardiovascular system, with additional effects in the respiratory system and the intestines. Vasoconstriction is a classic response to the administration of 5HT.
Neurons that secrete 5HT are termed serotonergic.
Depression, anxiety, insomnia and obesity can all be caused by a serotonin depletion.
excess serotonin causes migraine headaches
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| usmleasr
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SSRI s can cause,,, sexual dysfunction...
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