kiranmayi
Forum Guru
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What is the proposed mech of action of Lithium, and does your patient have hyper or hypothyroidism? What about poly- or oligouria?
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| dxtxpx
Forum Guru
Topics: 259
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Mech of action is not established; possibly related to inhibition of phosphoinositol casade(inhibition of conversion of IP2 to IP1 this results in dec IP3 production) . It also uncouples ADH and TSH receptors from adenyl cyclase that leads to dec cAMP. It causes dec release of thyroid hormones, blocks peripheral conversion of T4 to T3, goiter, polyuria, polydipsia, NDI
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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MOA: inhibits dephosphorylation of IP2 and IP1.
Also decrease cAMP .
it causes hypothyroidism and nephrogenic Diabetis insipidus..
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| robsanchez
Forum Junior
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produce inhibition of the phosphatidylinositol cycle, by inhibition of the dephosphorylation of IP2 to IP 1and IP1 to IP decreasing the recycling of inositol
It also produce Hypotiroidism by inhibition of 5' deiodinnse, and polyuria by coupled to ADH receptor ( nephrogenic Diabetes insipidus)
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| asmi
Forum Hero
Topics: 1043
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which protein kinase is involoved in here ?
1. protein kinase A
2. kinase M
3. kinase G
4. tyrosine kinase
5. kinase C
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| mjl1717
Forum Hero
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Since the MOA is still controversial that would not be the q .The q would lean more towards, indications, T.I., adverse rxns, drug-drug intereactions, [toxicity-(sodium polystyrene sulfonate)charcoal does nothing] some of the weird side effects-nephrogenic diabetes insipidus, hypothroidism, depressed t waves, leukocytosis, Seizures.
In answer to the q I saw phospholipse C mentioned in Goodman/Gillman
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| asmi
Forum Hero
Topics: 1043
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kaplan says it is via protein kinase C
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