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| Author | 13 Posts |
epica
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Cerebrohepatorenal syndrome results from the absence of all PEROXISOMAL enzymes in the brain, liver, and kidneys.
Clinical manifestations include craniofacial abnormalities, jaundice, hypotonia, hepatomegaly, and polycystic kidneys.
Do u know the name of this syndrome?
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| new_n_lost
Politically InCorrect
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Nope this one i have no clue at all
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Politically InCorrect
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R U Talking abt NALD Neonatal Adrenoleukodystrophy
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| me007
Forum Guru
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Zelwenger
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| me007
Forum Guru
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actually about adrenoleukodistrophy - same pathology in brain
X-linked adrenoleukodystrophy (X-ALD) is one of several inherited peroxisomal disorders characterized by progressive neurological dysfunction that is occasionally associated with adrenal insufficiency. The metabolic abnormality results from elevated levels of very long-chain fatty acids in tissues and plasma. The biochemical defect is reduced activity of very long-chain acyl-CoA synthetase (VLCS) in the peroxisome.
The typical pathological changes in childhood adrenoleukodystrophy cause diffuse white matter lesions usually starting in the occipital, parietal and temporal lobes. Macrophages in white matter are found filled with the very long chain fatty acids. There is loss of myelin with gliosis and perivascular chronic inflammatory cells are found. The adrenals and testes are also involved with accumulations of the storage material
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| new_n_lost
Politically InCorrect
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lol
U Girls R making me Sacred i Seriously Never Took Histology Seriously n Particularly peroxisomal thingy all i knew abt them was ALD there is a neonatal form which was not good n they survive less than 5 yrs
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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YES. ME007 IS RIGHT.
oK. HISTOLOGY IS NOT hy TOPIC FOR USMLE, WILL STOP POSTING
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| new_n_lost
Politically InCorrect
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Hey No way Alteast this Way WE or atleast i will get to revise some stuff this is the most untouched topic of USMLE.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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This was a Good Question Atleast it made me look into areas where i havent bothered to have a Second Look.
Plz Continue On
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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Ok
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| aml
Forum Senior
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Zellweger syndrome is where there is total absence of normal peroxisomes. Electron microscope reveals empty peroxisomes lacking enzymes. Manifests as cerebrohepatorenal problem and the infant dies within few months.
Adrenoleukodystrophy is caused by inability of peroxisomes to metabolise fatty acids. Lipids therby accumulate in the adrenal and nervous system.
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| dmdmd
Forum Newbie
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Gee, you guys are truly looking at zebras... @@
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| SmokyWaters
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zellweger
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