mytime
Go Marching in!
Topics: 40
Posts: 3,165
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 ? Ligands? EPICA u are depressing me girl on a Friday! 
D.???????????????????? 
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| epica
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Honestly, I don't know this subject, Help me...
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| new_n_lost
Forum Hero
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Posts: 6,393
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Cytosol ??
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"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 724
Posts: 6,393
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Well i can say that we all r here in the Same Boat u keep on Post ing th eQuestion n we will keep up with U,
___________________
"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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2.Ras proteins, which are indirectly coupled to receptors with ? kinase activity.
Please tell the name of this kinase
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| epica
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3.Mutant Ras proteins are associated with some neoplasms and most common is
1.Colon
2.Breast
3.ovary
4.lung
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| new_n_lost
Forum Hero
Topics: 724
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3. Lung and Ras proteins r bound to GTP proteins
___________________
"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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Ras- Colon toooo
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| epica
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Ras-- tyrosine kinase
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| new_n_lost
Forum Hero
Topics: 724
Posts: 6,393
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R u Sure cos Ras proteins r bound to GTP i just rechked in in Robbins
___________________
"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 724
Posts: 6,393
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n Tyrosine Kniase is for C-abl gene
___________________
"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 724
Posts: 6,393
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Mytime Can U plz Chk this point Out in the Robbins new edition or any one for that matter cos i have the Pocket version of th eRobbins for General Path while 6th edition original for Systemic path.
___________________
"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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Guys, please read, if it's mistakes I will stop to posting
1. Mutant Ras proteins are associated with some neoplasms (e.g., colorectal cancer).
* These defective Ras proteins are "turned on" in the absence of normal ligands, leading to neoplastic transformation of cells.
2. Cholera toxin modifies trimeric G proteins, causing them to remain in the active state in the absence of ligand.
* Resulting prolonged activation of G proteins → high cAMP levels → movement of water from the blood across the intestinal epithelial cells into the intestinal lumen → massive diarrhea with loss of isotonic fluid
3. Binding of α-bungarotoxin or curare to nicotinic ACh receptors in skeletal muscle cells leads to paralysis.
4. Graves' disease is an autoimmune disease in which TSH receptors are stimulated inappropriately by binding of immunoglobulin G (IgG) autoantibodies to the receptor.
* Manifestations include decreased levels of TSH, enlarged thyroid gland, and hyperthyroidism, leading to symptoms such as exophthalmos (bulging eyes), weight loss, fatigue, hand tremors, and nervousness.
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| epica
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Guys, please read, if it's mistakes I will stop to posting
1. Mutant Ras proteins are associated with some neoplasms (e.g., colorectal cancer).
* These defective Ras proteins are "turned on" in the absence of normal ligands, leading to neoplastic transformation of cells.
2. Cholera toxin modifies trimeric G proteins, causing them to remain in the active state in the absence of ligand.
* Resulting prolonged activation of G proteins → high cAMP levels → movement of water from the blood across the intestinal epithelial cells into the intestinal lumen → massive diarrhea with loss of isotonic fluid
3. Binding of α-bungarotoxin or curare to nicotinic ACh receptors in skeletal muscle cells leads to paralysis.
4. Graves' disease is an autoimmune disease in which TSH receptors are stimulated inappropriately by binding of immunoglobulin G (IgG) autoantibodies to the receptor.
* Manifestations include decreased levels of TSH, enlarged thyroid gland, and hyperthyroidism, leading to symptoms such as exophthalmos (bulging eyes), weight loss, fatigue, hand tremors, and nervousness.
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| epica
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Ok, guys, good point,nnl
"The GTP-bound form of Ras then binds to Raf protein. kinase (a MAPK kinase kinase) "
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| epica
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protein-tyrosine kinases, including phospholipase C-gamma, RAS GTPase ...
SO, it's Correct (new for me too)
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| mytime
Go Marching in!
Topics: 40
Posts: 3,165
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Which point NNL? And from what i remembered i answered D...the insulin Receptors involve tyrosine kinase activity.....so i chose D. cytosol cause al this is to happen at the membrane......
For the other one ras is most common in colorectal cancers..just read that.
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| mytime
Go Marching in!
Topics: 40
Posts: 3,165
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Hey HY histo page 8 receptor proteins, enzyme -linked receptors.
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| epica
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1, yes, Cytosol is correct for Q1
Thanks, guys
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