new_n_lost
Politically InCorrect
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A patient suffering from hemochromatosis classically presents with the following triad:
a) micro-nodular liver cirrhosis, iron deficiency anemia & diabetes mellitus
b) micro-nodular liver cirrhosis, diabetes mellitus & bronze pigmentation of skin
c) diabetes mellitus, sickle cell anemia, bronze pigmentation of skin
d) micro-nodular liver cirrhosis, diabetes mellitus & sickle cell anemia
e) micro-nodular liver cirrhosis, Kayser-Fleischer rings & diabetes mellitus
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| keepgoing
Forum Guru
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b?
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| mms
Forum Junior
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B
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| oldkidontheblock
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b
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| rock
Forum Elite
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b
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| new_n_lost
Politically InCorrect
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Politically InCorrect
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The correct answer is B
Explanation
Hemochromatosis is a condition caused by excessive iron accumulation in the body most of which is deposited in the parenchymal cells of various organs particularly liver and pancreas. The excess iron deposition in the parenchymal cells of various organs leads to dysfunction and ultimate failure of these organs. The organs most commonly affected are the liver and the pancreas. Liver undergoes micro-nodular cirrhosis due deposition of iron in the periportal hepatocytes and in pericanalicular lysosomes.
Bile duct epithelium and kupffer cell pigmentation is less marked. Pancreas becomes intensely pigmented, has interstitial fibrosis and parenchymal atrophy. Iron deposits are found in both acinar and islet cells. This responsible for pancreatic failure and development of diabetes mellitus. The intensity of iron staining in the pancreatic islets correlates with occurrence and severity of diabetes. Bronze pigmentation of skin is due to the deposition of iron in the dermal macrophages and fibroblasts.
So as per the above explanation a person suffering from hemochromatosis will present with a triad of micro-nodular liver cirrhosis, diabetes mellitus and bronze pigmentation of the skin. therefore the correct answer is B A,C,& D are not the correct answers because anemia-- sickle cell or iron deficiency is not a manifestation of hemochromatosis E is also incorrect because Kayser-Fleischer ring is seen in Wilson's disease and not in hemochromatosis.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| mytime
Kick my butt!
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