new_n_lost
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The presence of Anti-Jo-1 autoantibodies is most specific for:
a) Polymyositis
b) Ankylosing spondylitis
c) SLE
d) CREST syndrome
e) Sjögren’s Syndrome
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| arlete
Intern in 2009!!!!!
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A
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| sprint123
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| new_n_lost
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| new_n_lost
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The correct answer is A
Explanation
Anti-Jo-1 autoantibodies were originally described as precipitating autoantibodies in sera of patients with polymyositis. It was later realized that the anti-Jo-1 antibodies were specific for patients with polymyositis. The target for the anti-Jo-1 antibodies was one of a family of distinct cellular enzymes: the aminoacyl-tRNA synthetases.
The presence of autoantibodies against the Jo-1 antigen has been reported in up to 23% of polymyositis patients by immunodiffusion . Anti-Jo-1 antibodies are almost completely specific for myositis, being more common in polymyositis than dermatomyositis, and rare in children. The presence of anti-Jo-1 antibodies defines a distinct group of polymyositis patients with interstitial disease, arthritis, and fevers.
Anti-Mi-2 antibodies recognize a major protein of a nuclear complex formed by at least 7 proteins that is involved in the transcription process. Autoantibodies recognizing Mi-2 are considered specific serologic markers of dermatomyositis. They are detected in about 20% of patients with myositis and are associated with relatively acute onset, a good prognosis, and a good response to therapy.
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