Criggler najar,dubin,rotor gilbert

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Criggler najar,dubin,rotor gilbert

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5 Posts

sima
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Topics: 11
Posts: 114

03/29/07 - 06:59 PM

pls can some one explain me abttehse,i forget,so confusing. thanks

mytime
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Topics: 40
Posts: 3,169

03/29/07 - 07:24 PM

UNCONJUGATED HYPERBILIRUBINEMIA :

CRIGLER-NAJJAR Type1 ---- AR, -nt UGT1A1 activity, liver NL,colourless bile trace amount of unconjugated bilirubin, fatal in neonate. Transplant needed or dead by 18 months due to kernicterus.

CRIGLER-NAJJAR Type2 ---- AD, < UGT1A1 activity, NL liver, generally mild, High levels of unconjugated bilirubin,occasional kernicterus.Phenobarbital Rx can improve glucronidation.

GILBERT ---- AD, < UGT1A1 activity, NL liver, Jaundice might show up under stress, exercise,illness, fasting, anxiety. Discovered later in life.

mytime
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Topics: 40
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03/29/07 - 07:33 PM

CONJUGATED HYPERBILIRUBINEMIA :

DUBIN-JOHNSON ---- AR, multidrug resistance protein mutationlleading to impaired mutation of bilirubin glucronides, liver has pigmented cells, ?epinephrine, Chronic jaundice but nL life-span.

ROTOR---- Rare, AR, defects in hepatocellular uptake and excretion of bilirubin pigments.NL liver, jaundice but Nl lives.

mytime
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Topics: 40
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03/29/07 - 07:35 PM

Better now?

sima
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Topics: 11
Posts: 114

03/29/07 - 09:10 PM

thanks a bunch smiling face

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