new_n_lost
Forum Hero
Topics: 673
Posts: 6,144
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A Good Friend of Mine was Kinda thinking if we cud have a topic where we cud tell the difference bw the the following
1. Neuroleptic Malignant Syndrome
2. Tardive Dyskinesia
3. Serotonin Syndrome
4. Malignant Hyperthermia
These 4 normally have almost similar signs n symptoms n th ediagnosis is based upon History n certain specific Signs.
here they r
The History Will Tell u All For eg the presence of an Acute Clonus n Myoclonic Jerks n hyperthermia without the Addition of a Neuroleptic Drug Indicates Serotonin Syndrome. Neuroleptic malignant syndrome, associated with dopamine antagonists, has a slower onset of symptoms than SS and is associated with bradykinesia and "lead-pipe" muscular rigidity, rather than hyperkinesias and tremors. Furthermore SS will occur more in a Setting of a Suicide n with Atleast 2 drugs rather than a single drug alone. There will be Rhabdomyolysis n Renal failure in NMS
The triad of (1) altered mental status, (2) autonomic dysfunction, and (3) neuromuscular abnormalities that occurs on exposure to serotonergic agents characterizes the serotonin syndrome.
Tardive dyskinesias (TDs) are involuntary movements of the tongue, lips, face, trunk, and extremities that occur in patients treated with long-term dopaminergic antagonist medications.
Neuroleptic-induced TD is characterized by choreiform, athetoid, and rhythmic movements of the tongue, jaw, trunk, and extremities for at least 4 weeks that begin during treatment with neuroleptics or within 4 weeks of discontinuing neuroleptics. Diagnosis of neuroleptic-induced TD generally requires exposure to neuroleptics for at least 3 months. At least 1 month of exposure is typically required if the patient is aged 60 years or older. Oral and genital pain can be prominent manifestations of TD.
Malignant hyperthermia (MH) occurs after administration of halogenated inhalational anesthetics, such as halothane, and depolarizing muscle relaxants, such as succinylcholine, to genetically susceptible individuals. An underlying defect is an autosomal dominant mutation in the ryanodine receptor, which leads to excessive calcium release from the sarcoplasmic reticulum in skeletal muscle when one of the above agents is administered. A multifactorial pattern of inheritance also has been postulated. MH can be distinguished readily by history. Treatment is based on supportive care, use of dantrolene to decrease calcium release, and avoidance of precipitating medications.
Heat stroke can cause a similar picture, but patients have dry skin and flaccidity in addition to hyperthermia and hypotension
I will be adding more to them and Plz if u can too do so it help me & others a lot thank u
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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