mildus Forum Guru
Topics: 19 Posts: 614
| | 03/29/07 - 11:07 AM  
 
|   #1 |
glucagone has positive inotropic action
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| drmike11 Forum Junior

Topics: 8 Posts: 15
| | 03/30/07 - 12:06 AM  
 
|   #2 |
While true, this does not explain why glucagon would be used in this situation of other positive inotropes such as epinephrine. The big key here is cAMP. I wrote a nice post on my blog about this and it ties in the concept of physiologic antagonism.
___________________ My Blog, Mike's High Yield Blog for the USMLE Step 1
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| mms Forum Junior
Topics: 1 Posts: 72
| | 03/30/07 - 02:49 PM  
 
|   #3 |
glucagon stimulate adenylyl cyclase and increases intracellular cAMP in many different tissues. In the heart this result in increase of heart rate and force of contraction: it stimulate the depressed heart without needing the beta receptor that are blocked by the beta-blocker overdose!!!
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| ryan_cabrera Forum Newbie
Topics: 0 Posts: 10
| | 04/18/07 - 10:42 AM  
 
|   #4 |
I like! 
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| gotenks Forum Newbie
Topics: 3 Posts: 7
| | 04/20/07 - 12:06 PM  
 
|   #5 |
nice question.
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