new_n_lost
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I think the Response to them in the body is a Cell-Mediated one so I m guessing Type 4 for both Except in Tropical Pulmonary Esinophilia where the response is an IgE mediated.
Filariasis is included under Helminthiasis it goes to both
My 2 cents
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| me007
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wouldn't it be type 2 hypersensitivity in case of invasive helmints.
with eosinophils as effectors and igE attached to helmint - Fc fragment - to eosinophil?
and if someone know, what cells kill RBCs with plasmodiums in malaria?
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| indidoc1
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drsaleh wrote:
Which type of hypersensitivity reactions these are?
1.Filarial inf
2.Helminthiasis
i think both r type 2 antibody mediated responses.
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| indidoc1
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me007 wrote:
and if someone know, what cells kill RBCs with plasmodiums in malaria?
Phagocytes in spleen, as far as i know.
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| usmle4me
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It should be type 4 cell mediated. CD8 + cytotoxic T cell involved in hypersensitive reaction to malaria.So it is delayed type.
Not sure for filariasis though.
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| tompat
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too late !!
but the right ans wud be typeI, as this is generally a response to most helminths
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| doc179
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No its not type 1, its type 2.
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| tompat
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hi doc 179 do help me by explaining.
kaplan says type 1 for helminths ,its given in type 1 hypersensitivity reactions.
i m also a bit confused with type 1 and 2reactions.
by kaplan, type2 is generally a respose directed against autoantigens, they never mention any disease which involves type2 reaction and is directed against foreign antigen.here even though the antigen sometimes may be foreign the harm ful effects are inflicted on human cells e.g. cardiac lesions in rhuematic fever.
in type 1 reaction antihelmith anti body will be inducing mast cells n eosinophils to secret various inflammatory agents to kill helminths which can not be phagocytosed.
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| doc179
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type 1 hypersensitivity is the degranulation of mast cells and basophils when the surface IgE come in contact with an allergen , for which the pt has been previously exposed to.
But for parasitic infections thats not the case. The IgE molecules recognise the antigens and bind to them, the antigen-antibody complexes trigger a response which attracts the eosinophils to release major basic proteins and kill the parasite ( you might notice that I have not been thru this in great detail, since its been a longtime I studied this. But over all this is what happens ). So this becomes a type 2 hypersensitivity. ( I will go thru this again soon and whatever I might have missed, will get back to this thread and update ). I dont know if Kaplan says what you have just mentioned, I have an old book of kaplan but if you could let me know where , which page and all that stuff, I would definitely look it up. My friend has a new edition.
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| tompat
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i have read it in kaplan 2004 edition page no.435 n 436.
type 1 : reactions are mediated by IgE anti bidies for all helminths, here many IgE bind to mast cells and form a bridge on exposure to antigen causing their degranulation, leading to killing of parasite.
type2: has to be thru IgM or IgG and it s derected against our own antigen or any transplanted tissue. but its not mentioned any where that it is used to get read of any pathogen, even thou it might be indused by foregn antigen.
type3: inmmune complex mediated and involves complement , again thru IgM or IgG only.
type4: shud ve been initiated thru CD4+ cells, be delayed
thats what my understanding is,
thanks for replying, ur doing good in all subs man, dont worry
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| tompat
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| | 05/24/07 - 01:15 AM
2 of 2 forum leaders found this post helpful
| #12 |
as u might notice any hypersensitivity reaction involves immune -compleax formation except type4.
the key to distinguish them is who is the mediator and whether it is localized or systemic.
type 1: IgE
type 2: IgG or IgM and ITS LOCALISED be it distruction of cells or altering their fun
type 3: immune complex mediated and is SYSTEMIC ,meaning these complex originate some where and produce effects where ever they get deposited
type 4: thru CD4+ cells i dont think there will be any confusion over this type of reaction
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| doc179
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| | 05/24/07 - 01:37 AM
1 of 3 forum leaders found this post helpful
| #13 |
I have not gone thru the kaplan notes yet but the link below is from this forum where this has been discussed before and tolito has explained it very nicely. This is just a reference and I would definitely go thru the notes. I was also under the impression that its type 1 but after a lot of discussions now I think its type 2. http://www.prep4usmle.com/forum/comments.php?id=3...
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| doc179
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| | 05/24/07 - 01:41 AM
2 of 2 forum leaders found this post helpful
| #14 |
http://www.prep4usmle.com/forum/comments.php?id=3...
looks like this is a more useful link
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| doc179
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http://www.prep4usmle.com/forum/comments.php?id=3...
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