mytime
Kick my butt!
Topics: 39
Posts: 3,174
|
85% of Po4 is reabsorbed in PCT via Na+ Po4 cotransport So if that's happening shouldn't Ca2+ be going out in high Na+ diet, just a guess. Am sure there's more to it.
|
| Luckyall
Forum Guru
Topics: 11
Posts: 592
|
okay, lets try this:
a high Na diet will stimulate ANP secretion----> wich will increase diurez.& Na-uresis by inhibiting Na and H2O reabsor. in CD
If inhibit. Na/Cl. cotransporter in CD ----->Cl wont be reabsorbed inside the Cd tubular cell----> wont be reabsorbed in the interstitium blood thru the Cl channel on basolateral mb---> the net effect is decreased Ca reabsorb. from the lumen at this CD level----> therefore Ca -uria
|
| mytime
Kick my butt!
Topics: 39
Posts: 3,174
|
Ok here goes ur ans. Ca2+ reabsorption is linked to Na+ reabsorption in Loop of henle hence, Increased Na+ diet should decrease the reabsorption of Na+ , hence Ca2+ too!? 
|
| Luckyall
Forum Guru
Topics: 11
Posts: 592
|
and why would an incr in Na diet lead to a DECREASE in Na reabs??? i bc the pump is not TM saturable . I think most of Na should be reabs. in PT (2/3), so the more you have, more is reabs.. think of Thiazides .... and Ca- uria
|
| Luckyall
Forum Guru
Topics: 11
Posts: 592
|
meant to say CD ---thiazides-- ca-uria
However Na/K/Cl pump at the loop of henle is NOT Tm saturable for sure...
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
My 2 Cents
Renal calcium reabsorption is directly proportional to sodium reabsorption. When dietary sodium chloride is increased, the fractional reabsorption of sodium is decreased, leading to a parallel reduction in calcium reabsorption. Approximately 1 mmol calcium is excreted for every 100 mmol of sodium excreted. Calcium is reabsorbed 60% in the Proximal Tubule n so on till the Loop of Henle. Only PTH dictates the DCT reabsorption. Most of the Substances transported thru the Na Cotransporters While a Cl Ca Channel has been identified n implicated in this CAse (Dent's Disease).
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| Luckyall
Forum Guru
Topics: 11
Posts: 592
|
and where exactlly did you search for these " 2cents" thoughts... b c is not true according with a Qs i found...
it says " Ca is usually reabs. in DCT. Theoretically , Cl- is reabs thru thiazide sensitive Na/Cl and transported from the cell thru the basolateral Cl chann.--> decreasing intracell. Cl- conc.Net effect is incr. activity of voltage depend, Ca chann.-----> incr. electical gradient for Ca rabs. from lumen. "
The Ca reabs in DCT is not ONLY PTH dictated.
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
lol Buddy lmao 
I didnt have to Search Anywhere buddy its in Ganong
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
Look Under Calcium Balance in Endocrine Section n in Renal Chapters
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| epica
|
90% Ca is reabs. in PT an TAL.
NNL, your explanation is correct, just from the Basic science.
|
| mytime
Kick my butt!
Topics: 39
Posts: 3,174
|
That's what i said in my way!!!!!!!!!!! 
|
| epica
|
Yep, u were right , mytime
I like your "smiles", I downloaded them too, thanks.
|
| mytime
Kick my butt!
Topics: 39
Posts: 3,174
|
 
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
lol 
Mytime U r charged Right now !!!!!!!! Battery Full Charged Neend bhi Full Charged.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
|
dont know but cud it be bcos high sodium intake---->inc Na reabsorptn --->hence inc calcium(hypercalcemia)---> increase calcium --->inhibit PTH --> hence Hypocalcemia and inc calcium excreation...
|
|
| |
| | | | | | | | | | | | | | | |
