DrVirgo
Forum Hero
Topics: 1096
Posts: 3,515
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Whats the difference between:
1) A person who has been vaccinated and shows NO documented response to the vaccine
AND
2) A person who is a NON-Responder???
I'm asking because according to UW:
in case of 1 - we have to give a 2nd course of vaccination upon needle stick exposure
in case of 2 - we have to give HB Ig upon needle stick exposure
Since vaccinated people have surface antibody (HBsAb), i guess NO documented response would be someone who was never tested to see if he has sAb ??? And a non-responder would be NO sAB after vaccination.....?????
Let me know if i should post the question.
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| huyniid
Forum Elite
Topics: 9
Posts: 195
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I think that person with no documented vaccin response (after vaccination, they have no anti-HBs Abs) because there is some mutation in the antigen after vaccinated --> considered as not vaccinated--> Full course vaccine again and HBiG for postexposure prophylaxis
Non-responder is defined as anti-HBs < 10 U/mcl after vaccination --> it is also consider as protective, but not for a long time. In postexposure prophylaxis--> HBIG is needed
If it is possible, pls post the full Qs
good luck
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