fongch wrote:
The answer by Kaplan is C, but personally I still believe B is the correct answer.
what explanation does kaplan give?
Got this of emedicine
* Bone marrow aspiration and biopsy with flow cytometry is not required in all cases but may be necessary in selected cases to establish the diagnosis and to assess other complicating features such as anemia and thrombocytopenia. For example, bone marrow examination may be necessary to distinguish between thrombocytopenia of peripheral destruction (in the spleen) and that due to marrow infiltration.
* Consider a lymph node biopsy if lymph node(s) begin to enlarge rapidly in a patient with known CLL to assess the possibility of transformation to a high-grade lymphoma. When such transformation is accompanied by fever, weight loss, and pain, it is termed Richter syndrome.
Edited by hypochondriac on 03/27/07 - 04:34 PM
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| AAAAA
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C is a reasonably right answer
Most CLL patients are above 60 years old, and try not to do an invasive testing, a peripheral LN is sufficient to make the diagnosis
But for multiple myeloma, a bone marrow biopsy is necessary
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| AAAAA
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excisional biopsy or needle biopsy ????
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The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. This atypical molecular pattern includes the co-expression of cells surface markers CD5 and CD 23
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| Justice
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To AAAAA:
This is still C, and the biopsy is incisional since they also look at the architecture of the LN;
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| AAAAA
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C is correct, same as Hopkin's Lyphoma, use excisional biopsy on cervical LN , you don't use a big gun on bone marrow.
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