ling
Forum Senior
Topics: 23
Posts: 46
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. A 52-year-old woman comes to the physician because of decreased libido; this symptom began 8 months ago, after she underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy for leiomyomata uteri and menorrhagia. She has been taking hormone replacement therapy with conjugated estrogen since the operation. Examination shows a moist, rugated vagina. Which of the following is the most likely cause of these findings?
A
) Decreased androgens
B
) Decreased estrogen
C
) Decreased follicle-stimulating hormone (FSH)
D
) Decreased luteinizing hormone (LH)
E
) Decreased progesterone
F
) Decreased prolactin
G
) Increased androgens
H
) Increased estrogen
I
) Increased FSH
J
) Increased LH
K
) Increased progesterone
L
) Increased prolactin
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| robin082006
Forum Hero
Topics: 471
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A) Decreased androgens
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| yasmeen
Forum Guru
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DEC ANDROGENS
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| damngood
Forum Newbie
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can you explain why androgen
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| arlete
Half way there!
Topics: 43
Posts: 3,105
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Androgen is the hormone responsable for libido, it decreases once the ovary is removed.
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| fongch
Forum Elite
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But estrogen will be converted to androgen in the peripheral tissue, right? Since this woman is on estrogen replacement, how can androgen be low?
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| radonc
Forum Senior
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Oestrogen is NOT converted to androgen (or testesterone and its related compounds). Androgens, however, are the precursor of all oestrogens. Oestrogens are mainly produced in the ovaries, with smaller amounts in adrenal cortex and other organs.
Since this woman is taking oestrogen replacement, it would exert negative feedback on the hypothal-pituitary axis, reducing the secretion of LH (and FSH). Reduced LH accounts for the decreased androgen production, hence less libido.
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| fongch
Forum Elite
Topics: 71
Posts: 316
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Thanks, Radonc
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