new_n_lost
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A baby is born with a testicular mass. Histologic sections made of the homogeneous yellow-white mass after its removal demonstrate epithelial-lined spaces that have flattened-to-cuboidal epithelial cells with vacuolated cytoplasm containing eosinophilic, hyaline-like globules. Scattered structures resembling primitive glomeruli (endodermal sinuses) are also seen. If appropriate
immunohistochemical stains are performed, the eosinophilic cytoplasmic globules would most likely contain which of the following?
A. Alpha-fetoprotein
B. Estrogen receptors
C. Human chorionic gonadotropin
D. Human papilloma virus
E. Melanin
Explain Ur Answers Plz
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| rock
Forum Elite
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i have no clue...whats the answer to this one nnl
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| usmle4me
Forum Elite
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Positively thinking it is a yolk sac tumour and it has high AFP
Answer A
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| new_n_lost
Politically InCorrect
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Anyone Else wants to give it a try
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| shalini.ravi
Forum Senior
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c
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mediocricity aint my style
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| new_n_lost
Politically InCorrect
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Yup usmle4me u r right.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Politically InCorrect
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The correct answer is A
The malignant tumor is a yolk sac tumor, also known as infantile embryonic carcinoma and endodermal sinus tumor. The biggest tip-off in the question stem is the presence of endodermal sinuses that resemble primitive glomeruli. The cytoplasmic globules described contain alpha-fetoprotein, indicating yolk cell differentiation, and alpha-1-antitrypsin. Alpha-fetoprotein can also be used as a serum marker for recurrent disease. Yolk sac tumors occur in pure form in infants and children and may be part of mixed tumors in adults.
Estrogen receptors (choice B) are important markers in breast cancer because they predict tumor response to hormonal manipulation.
Human chorionic gonadotropin (choice C) is found in the syncytial cells of embryonic carcinoma.
Human papilloma virus (choice D) can be found in condylomas, cervical cancer, penile cancer, laryngeal polyps, and warts.
Melanin (choice E) can be found in melanomas.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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