Prep4USMLE Forum » USMLE Step 1 Forum » Pathology Forum |   Hepatopulmonary syndrome

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Medusin Forum Elite Topics: 17 Posts: 279	03/21/07 - 10:42 PM             #1 Can somebody explain the pathphysiology behinf the hepatopulmonary syndrome? (Specially in Cirrhosis)? Thanks! ___________________ What Starts Here Changes The World
new_n_lost Politically InCorrect Topics: 650 Posts: 6,058	03/22/07 - 01:44 PM             #2 The hepatopulmonary syndrome results from the formation of microscopic intrapulmonary arteriovenous dilatations in patients with chronic liver disease. The mechanism is unknown but is thought to be due to increased hepatic production or decreased hepatic clearance of vasodilators, possibly involving nitric oxide. The vascular dilatations cause overperfusion relative to ventilation, leading to hypoxemia. Because the lesions frequently are more numerous at the lung bases, the hepatopulmonary syndrome causes platypnea (dyspnea) and orthodeoxia (hypoxemia) in the seated or upright position that subside with recumbency. Most patients also have stigmata of chronic liver disease, such as spider angiomas. About 20% of patients, however, present with pulmonary symptoms alone. http://www.merck.com/mmpe/print/sec05/ch058/ch058... ___________________ FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
Medusin Forum Elite Topics: 17 Posts: 279	03/22/07 - 06:16 PM             #3 Ok! Thank you very much! Is it also associated with clubbing of the fingers? Is the pathophysiology of this clinical sign known? ___________________ What Starts Here Changes The World
Medusin Forum Elite Topics: 17 Posts: 279	03/22/07 - 06:16 PM             #4 Is estrogen metabolism involved in the vasodilation? ___________________ What Starts Here Changes The World
new_n_lost Politically InCorrect Topics: 650 Posts: 6,058	03/22/07 - 08:38 PM             #5 Budy plz go thru the following Links:- http://www.annals.org/cgi/content/full/122/7/521 http://medicine.ucsf.edu/housestaff/Chiefs_cover_... http://medicine.ucsf.edu/housestaff/Chiefs_cover_... ___________________ FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
Medusin Forum Elite Topics: 17 Posts: 279	03/22/07 - 10:37 PM             #6 ok thanks... ___________________ What Starts Here Changes The World

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