new_n_lost
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A 9-month-old baby was vaccinated against smallpox with attenuated smallpox virus. He developed a progressive necrotic lesion of the skin, muscles, and subcutaneous tissue at the site of inoculation. The vaccination reaction probably resulted from
A) B-lymphocyte deficiency.
B) Reaction to the adjuvant.
C) Complement deficiency.
D) T-cell deficiency.
E) B- and T-lymphocyte deficiency.
Explanation is Required
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| doc179
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because there is only a local response at the site of injection and no other immunodeficiency symptoms in the history mentioned I opt B
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| sm1986
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agree with doc179..
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| keepgoing
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d?
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| indidoc1
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Same here.. i also opt fr B.. Same reason
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| rock
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D ??
the reaction could be a result of some kind of immunodeficiency in the child and this child should not have been vaccinated but there is no such history so i am not so sure about the answer.
cell mediated immunity is needed against viruses and so could be T cell deficiency.
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| rock
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is this vaccinia necrosum?
http://www.bt.cdc.gov/agent/smallpox/vaccination/...
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| usmle4me
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At site of inocculation---> T cell deficency
Genralised-----> B cell deficency
Severe case with both ---> SCID
Shall go for D---> T cell def
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| new_n_lost
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D T-cell deficiency would result in the absence of the crucial immunologic defenses against viral infection, that is, cell-mediated immunity. Cell-mediated immunity plays the major role in immunity to viral infections, much greater than the roles of antibody or complement. In fact, individuals with impaired T-cell-mediated immunity should not be vaccinated with live virus, which, even if attenuated, may cause a serious infection.
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| doc179
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thanx for the correct ans and the explanation NNL. would you also pls let us know why its not B ? and I have been thinking whether all vaccines have adjuvants as adjuvants I think can be given with a killed or a component vaccine to enhance the immune response to it. But is an adjuvant required for an attenuated and a live vaccine as well?
Thanx
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| new_n_lost
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Doc179.............. Buddy there wasnt any explanation for the other choices, The only reason i cud think of was that wud we give an adjuvant to a 9 mnth old baby.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| doc179
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I think adjuvants are present in every vaccine. When I was opting for B the only doubt I had was whether adjuvants are used in attenuated and live vaccines as these vaccines are capable of inducing an effecient immune response.
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| rock
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i think reaction to the adjuvant in the vaccine will be more generalised...just thinking about possible explanations
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| doc179
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I dont think it can be generalised but it can definitely be less intense than the one this child has ( may be just an abcess ) ???
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| rock
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could be...i am not sure about this myself(if reaction to adjuvant is generalised or not)...if i find out i'll post it here
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