new_n_lost
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A 50-year-old worker at an atomic plant who previously had a sample of his own bone marrow cryopreserved was accidentally exposed to a minimal lethal dose of radiation. He was subsequently transplanted with his own bone marrow. This individual can expect
A) to have recurrent bacterial infections.
B) to have serious fungal infections due to deficiency in cell-mediated immunity.
C) to make antibody responses to thymus-independent antigens only.
D) All of the above.
E) None of the above.
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| doc179
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E ?
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| indidoc1
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hmm.. not sure.. maybe E..
Coz it ws a lethal dose of radiation.. no antigenic mutants would have survived. 
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| keepgoing
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seems like e no other options suffics..
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| new_n_lost
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E The autologous bone marrow cells, which contain stem cells, will replicate, differentiate, and repopulate the hematopoietic-reticuloendothelial system, rendering the individual immunologically normal. As such, the individual is not expected to have bacterial, viral, or fungal infections or to respond to antigens differently from a normal individual.
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| tompat
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hi nnl,
cud u please explain me what happens to thymus after such kind of radiation exposure if the same dose can suppress bone marrow.
i think it wud also completely destroy thymus gland,oh yah its active in adults, no doubt.
in this case BM transplant will replenish all stem cells but what wud happen to T cell maturation.
please bear with me
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