new_n_lost
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An 8-month-old baby has a history of repeated gram-positive bacterial infections. The most probable cause for this condition is that
A) the mother did not confer sufficient immunity on the baby in utero.
B) the baby suffers from erythroblastosis fetalis (hemolytic disease of the newborn).
C) the baby has a defect in the alternative complement pathway.
D) the baby is allergic to the mother's milk.
E) None of the above.
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| doc179
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E
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| indidoc1
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very vague question.. all i cn say is.. mum had nothing to do wth it coz he's over 6 months old.
n i don't think milk allergy's got anything to do wth it..
Late complement deficiencies may lead to pyogenic infections.. but it cn easily be anything else also.
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| new_n_lost
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its a tricky one Indi Concerntrate
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| indidoc1
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| doc179
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second thought: is it D ? this is why I now feelthat the answer might be D: if the baby has selective IgA deficiency, it will have antibodies to IgA present in mother's blood and will be allergic to it and will also have recurrent bacterial infections.
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| new_n_lost
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E None of the above is likely to be the underlying cause for the history. The baby is probably hypogammaglobulinemic. Hypogammaglobulinemia leads to recurrent bacterial infections. Viral and fungal infections are controlled by cell-mediated immunity, which is normal in hypogammaglobulinemic individuals.
Answer A is incorrect because the mother's IgG, which passed through the placenta, would have a half-life of 23 days, and would therefore not be expected to remain in the baby's circulation for 8 months. At this age any Ig present in the baby's circulation is synthesized by the baby.
Answer B is irrelevant, since Erythroblastosis fetalis is caused by the destruction of the newborn's Rh+ erythrocytes by the Rh- mother's antibodies to Rh antigen.
Answer C is unlikely since the classical complement pathway would still be protective; moreover, a defect in the alternative pathway would not result in the selective inability to protect from only gram-positive bacterial infections.
Answer D is incorrect since, even if allergic to the mother's milk, the baby should not suffer from increased frequency of bacterial infections.
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| keepgoing
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E
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| indidoc1
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Just 1 Q... why ll a hypogammaglobulinemic child suffer frm GRAM+ infections only??
y not Gram- also?
i agree wth the ans.. but just asking fr my knowledge.
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| new_n_lost
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Encapsulated bacteria such as Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus are the most common pathogens. Bordetella pertussis may play an important role in respiratory infections
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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Dont know y the Gram -ve arent involved or are involved
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| jole
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i think that gram negative bacteria can activate the alternative compliment system and get killed.but gram + bacteria need to be opsonized mainly by IgG to be killed ;if this child has hypogammaglobulinemia he will be incapable of eliminating gram bacteria. Thats what i think.
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