mjl1717
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Can anyone name some (not so common) pathologic terms used to describe the pathogenesis of Diabetes Mellitus?
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| drmka
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Honeymoon period....u have almost %20 of B cells.Juvenil and Type 1...
insulin resistance..For type 2.....
Stiffman Syndrome...there are autoantibodies against insulin...
impaired insulin secretion...Type II
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| mjl1717
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One of the things about this field is that things change.
1)From what I understand no more Type I or Type II
both come under Diabetes Mellitus (because insulin is sometimes
used in type II-(took the powers that be a long time to figure that out)
This is in the 15th edition of Harrison.
2) The main test is the fasting test which should be below 110mg/dl
between 110 and 126 is called impaired glucose fasting
3)back to key terms- HLA-DR3,HLA-DR4,HLA-DQ.
4) Osmotic damage
5) Advanced glycosylation end products-(AGE)
6) amyloid deposits
7) hyaline arteriosclerosis
8) Armanni Ebstein lesions
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| asmi
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thanks mjl for the info..
Armanni Ebstein lesions , whats that ?
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| mjl1717
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Armanni Ebstein lesions refers to some of the pathogenesis of DM is the kidney tubules-[there is vacuolization of cells of the proximal convuluted tubule]
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| asmi
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nonenzymatic glycosylation (NEG)...hyaline arteriosclerosis( nephropathy) and macrovascular disease(CAD,CVA,PVD)
i think AGE which you have mentioned is same to NGE..
among kidney lesions...nodular glomerulosclerosis ,papillary necrosis,diffuse GS, arteriolar nephrosclerosis .
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| asmi
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thanks mjl 
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| mjl1717
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yeah that NEG that you talk of is a key phrase in this pathogenesis
imagine that- you could read a large book about enzymes but in this particular pathology "none" are needed :!:
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