goodies
Forum Junior
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why does anemia cause rouleaux? if there are fewer RBC's due to anemia, wouldn't it be less crowded in the RBC so less likely to rouleaux, but that's not the case (according to Goljan RR Ch2) ... and I don't know why!
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| epica
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Rouleaux are linear, stacked arrangements of erythrocytes that occur on blood smears, often as a result of high SERUM FIBRINOGEN or antibody concentrations. This phenomenon may resemble agglutination
http://www.vetmed.auburn.edu/distance/clinpath/mo...
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| paganini
Forum Senior
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I am not sure in the case of anemia but I think that anemia promotes rouleaux because there is less hemoglobin, hemoglobin provides negative charges to RBC, if there is LESS negative charges to repel each other this can promote rouleaux. In the case of fibrinogen and other proteins the explanation is easy, here is beacuse you have elevation in plasma of proteins with positive charge.
Edited by paganini on 03/17/07 - 02:11 PM. Reason: LESS NEGATIVE CHARGES, I forgot to write the word LESS.
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| new_n_lost
Politically InCorrect
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Yup u r right Goljan in the New RR says the same thing which Paganini abt negative charge has said.
" Increased Fibrinogen (acute -phase reactant) in plasma decreases the NEGATIVE charge in RBCs promoting Rouleaux formation. Anemia Does produce Rouleaux formation but Abnormally shaped RBCs dont
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| goodies
Forum Junior
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i thought the negative charge of RBCs was due to proteins on the external surface of the RBC membrane and not exactly due to the Hb? goljan didn't explain why anemia promotes rouleaux...
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| new_n_lost
Politically InCorrect
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Look at the Explanation given by Paganini its the right one. Further information can be searched on Internet as we will do so also n if u find the answer be sure to post it in the meanwhile we r searching for it.
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| Ig F
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thatz a new piece of info.....as i havent read tht in goljan either.......
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| Ig F
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The RBC's have stacked together in long chains. This is known as "rouleaux formation" and it happens with increased serum proteins, particularly fibrinogen and globulins. Such long chains of RBC's sediment more readily. This is the mechanism for the sedimentation rate, which increases non-specifically with inflammation and increased "acute phase" serum proteins.this one is from webpath guyz
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