new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
A 45 year old man has Duke’s C adenocarcinoma of the colon. There is a strong family history of colon cancer in the absence of polyps. What is the most likely genetic basis?
A. Mismatch repair genes
B. Ras
C. Deletion in colon cancer
D. P glycoprotein gene
E. APC gene
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| doc179
Forum Guru
Topics: 67
Posts: 1,217
|
mismatch repair
|
| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
|
a
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
The Correct Answer is A
History is most consistent with HNPCC
HNPCC is linked to mutations caused by microsatellite instability in several mismatch repair genes, notably hMSH2 & hMLH1. As a result, there is defect repair of DNA mismatches with abnormal cell growth & tumour development. The majority of these mutations are inactivating insertions or deletions.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
|
| |
| | | | |
