new_n_lost
Politically InCorrect
Topics: 652
Posts: 6,067
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Which of the following most specifically describes the use of linkage analysis in the search for a disease specific gene in a family?
A.The correlation of a DNA polymorphism with a family specific mutation
B.The finding of an association of a DNA polymorphism with the clinical phenotype
C.The drawing of a pedigree & to find who is normal & who is affected
D.To access a large pedigree & be able to obtain DNA from most of the family members
E.The drawing of a pedigree & to exclude the potential of non-paternity
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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B
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| mytime
Kick my butt!
Topics: 39
Posts: 3,174
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Kinda confused but C?
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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yeah...looks like C might be right....
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| keepgoing
Forum Guru
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Posts: 1,673
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yes either b or c
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| new_n_lost
Politically InCorrect
Topics: 652
Posts: 6,067
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Doc 179 U were right the first time
The Correct Answer is B
Linkage analysis methods all rest on the biological phenomenon of recombination of homologous chromosomes. During meiosis homologous chromosomes pair up and exchange material. The probability of a recombination event occurring between loci far apart on a single chromosome is larger than for loci closer together. Hence, alleles at loci near each other are generally inherited (or co-segregate) together, making it possible to follow transmission from generation to generation at unknown loci by using alleles at neighbouring loci (i.e. the neighbouring locus alleles act as surrogates for the presence of alleles at other loci).
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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