Genetics 2

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Genetics 2

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new_n_lost
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03/16/07 - 01:55 PM

Which of the following is most suggestive of a mitochondrial DNA defect as the cause of a genetic disease?

A.Autosomal pattern of transmission
B.Maternal pattern of transmission
C.The finding of a cardiomyopathy
D.A change in the mitochondrial DNA sequence
E.The presence of somatic mosiacism

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mytime
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03/16/07 - 02:11 PM

E..... i think

doc179
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03/16/07 - 03:27 PM

mytime
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03/16/07 - 09:05 PM

Of course it's maternal transmission...but with mosiacism ssssssssssssssssoooooooooo?

new_n_lost
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03/16/07 - 10:04 PM

Maternal pattern of transmission

Mitochondrial inheritance

2 distinctive features.

matrilineal inheritance.
both sexes affected but transmission only by females as mitochondria are only maternally derived.
hetroplasmy.
the presence of both normal & mutation carrying mitochondrial DNA in a cell ��" explains wide phenotypic variation between affected individuals in a family.

Edited by new_n_lost on 03/16/07 - 10:18 PM

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keepgoing
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03/17/07 - 03:58 AM

B..

nnl why u post ans soon... sad

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new_n_lost
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03/17/07 - 10:49 AM

Sorry KG will wait next time

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alirizvi
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09/27/08 - 08:52 PM

i know B is right but why not D ?

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GoodGirl
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10/01/08 - 07:48 AM

alirizvi wrote:
i know B is right but why not D ?

Which of the following is most suggestive of a mitochondrial DNA defect as the cause of a genetic disease?

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